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[7] [12] However, Phase 2 trials are not powered to detect rare cardiovascular outcomes, and longer-term Phase 3 data including dedicated cardiovascular outcome trials will be essential to fully characterise the cardiac safety profile of retatrutide

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Open question Whether the same mechanisms are clinically meaningful in humans is not yet established

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doi: 10.1016/j.tem.2016.03.017 81 SlleyEKunSSzijrtIAKertszMWittmannIMolnrGA

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