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Based on receptor-mediated targeting, BDPR NSs can effectively cross the BBB, target dopaminergic neurons, specifically clear ROS and reduce iron aggregation in PD lesions, and exhibit good neuroprotective effects in PD cell, nematode, and mouse models (226)
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Therefore, pyran-methyl-pyridine and methoxy-methylbenzene were substituted at the same positions to enhance selectivity toward PDE1B, leading to Compound 11
Zhou X, An B, Lin Y, Ni Y, Zhao X, Liang X
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