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Targeting the incretin system in obesity and type 2 diabetes mellitus
MAESTRO: a randomized, double-blind phase III study of evofosfamide (Evo) in combination with gemcitabine (Gem) in previously untreated patients (pts) with metastatic or locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC)
Eun SY, Seo J, Park SW et al (2014) LPS potentiates nucleotide-induced inflammatory gene expression in macrophages via the upregulation of P2Y2 receptor
Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints
Together, they target the structural repair mechanisms that conventional medicine largely ignores: collagen synthesis, connective tissue remodeling, angiogenesis at the injury site, and nerve repair
