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Farr OM, Sofopoulos M, Tsoukas MA, et al
No GLP-1 also improves insulin sensitivity, glucose handling, fat metabolism, and overall energy balance
The mechanism is that GLP-1 exerts its glucagon inhibitory effect in human pancreatic islets through an intrinsic (non-paracrine) PKA-dependent effect mediated by the activation of the few GLP-1Rs present in the plasma membrane of -cells, which ultimately inhibits P/Q-type Ca2+ channels ( in vivo ( GLP-1R is present not only in -cells and -cells, but also in -cells
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