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Light-headedness occurring shortly after standing up (within seconds to minutes) suggests orthostatic hypotension (a drop of 20 mmHg systolic or 10 mmHg diastolic blood pressure within 3 minutes of standing), whilst symptoms appearing 24 hours after meals may indicate postprandial blood glucose fluctuations, particularly in patients taking additional glucose-lowering agents

The proportion of patients who had ongoing treatment, regardless of previous discontinuation episodes, ranged between approximately 70% and 80% for both drugs during a 15 year period after treatment initiation across analyses using various grace periods

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GLP-1 may decrease sodium reabsorption, thus increasing NaCl delivery to the macula densa

Some people who were previously struggling to lose weight on GLP-1 therapy alone find that addressing their depression with bupropion unlocks the lifestyle changes needed for the medication to work as intended