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Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

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Second, restricts distribution and is subject to active efflux, yielding heterogeneous brain exposure across regions and patients

It has also been discovered to be necessary for the development and maintenance of skeletal and muscle tissue, and to raise IGF-1, or Insulin-like Growth Factor 1

Jastreboff et al., NEJM, 2023