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These enzymes play a critical role in cellular defense by catalyzing the conjugation of electrophilic compounds with glutathione, thereby facilitating the neutralization of carcinogens, reduction of lipid peroxides, regeneration of oxidized thiol groups, and repair of damaged membrane phospholipids (2830)

The genes encoding these enzymes are known to be highly polymorphic

pmid:22666515 13

Increased eryptosis in patients with primary antiphospholipid syndrome (APS): a new actor in the pathogenesis of APS

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