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Randomized controlled trial evidence The most recent and comprehensive meta-analysis comes from the Journal of the American Heart Association, published in 2025
Some people may be able to drink small amounts of alcohol while taking retatrutide, but alcohol may feel different and may worsen side effects
Along with their antioxidant properties, GLP-1 RAs also demonstrate considerable anti-inflammatory effects, further diminishing the pro-inflammatory environment that accelerates aging
FDA-APPROVED INDICATIONS Type 2 diabetes As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus Limitations of use: has not been studied in patients with a history of pancreatitis TYPE 2 DIABETES RCT SURPASS-2 trial - Tirzepatide vs Semaglutide in Patients with Type 2 Diabetes, NEJM (2021) [PubMed abstract] The SURPASS-2 trial enrolled 1879 adults with type 2 diabetes who were inadequately controlled with metformin at a dose of at least 1500 mg per day Main inclusion criteria Age 18 years T2DM uncontrolled with metformin at 1500 mg/day A1C of 7 - 10.5% BMI 25 and stable for 3 months Main exclusion criteria Type 1 diabetes GFR 50 ng/L
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