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In the present trial, all available doses of tirzepatide were compared with semaglutide 1 mg, showing that even the lowest tested dose of tirzepatide (5 mg) enabled a greater proportion of participants to achieve therapeutic goals compared with semaglutide 1 mg

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Weight loss improves metabolic markers, but the cellular machinery for processing energy, meaning mitochondrial function, may need separate support, particularly in individuals with long-standing metabolic dysfunction

85 Naltrexone was also reported to show certain promise in regard to brain fog and fatigue, nevertheless, current clinical trials are still in the recruiting phase at the time of writing this article