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Prenatal exposure to these substances results in cortical thinning and hyperproliferation in fetal rats, while not affecting neuronal differentiation
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins
PMID: 9488001 Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL
However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance
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