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Weight loss averages 11 to 15 percent of starting body weight by month 6

In SURMOUNT-5, at 24 weeks, tirzepatide 10 or 15 mg led to an estimated mean percentage weight reduction of 14.4% (95% CI 15.0% to 13.8%) compared with 10.8% (95% CI 11.4% to 10.2%) for semaglutide 1.7 or 2.4 mg (efficacy estimand)

Abdominal pain Constipation Diarrhea Nausea Vomiting These side effects are usually mild and tend to diminish as your body adjusts to the medication

Rybelsus EPAR summary page

Why Standard Dosing Protocols Exist Pharmaceutical companies spend years developing optimal dosing schedules for GLP-1 medications through rigorous clinical trials