Absorption is greater in the fasting state and reduced by factors such as certain foods, malabsorption, or concurrent use of agents like aluminum hydroxide, proton pump inhibitors, and calcium or iron supplements (Antonini et al
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SGLT2 inhibitors In people with type 2 diabetes, cardiovascular outcome trials (CVOTs) with empagliflozin, canagliflozin and dapagliflozin have established that use of these SGLT2 inhibitors reduces the risk of CV events (quantified as a composite of non-fatal myocardial infarction, non-fatal stroke and CV death) versus placebo in: Established atherosclerotic CV disease (ASCVD
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Therefore, this review aims to synthesize the evidence on the mechanistic expansion of GLP-1RAs from metabolic regulators to systemic modulators of inflammation, autophagy, and organ protection, and explores their therapeutic repurposing across diseases