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In Vivo Assessment Of Drug Interactions Effects Of Sitagliptin On Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraception (ethinyl estradiol and norethindrone) (Table 5), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)

Microdosing may provide benefits without the gastrointestinal distress associated with traditional dosing

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The combinational therapy of NaB with GLP-1 has great potential to alleviate NAFL and NASH