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PubMed Central Gantz, I., & Fong, T
The entry of -KG into the TCA cycle is highly regulated: Pyruvate Dehydrogenase Complex (PDC): The conversion of pyruvate to acetyl-CoA is tightly regulated by the PDC complex, which can be inhibited by acetyl-CoA (feedback inhibition) and activated by ADP
Moreover, excessive alcohol consumption elevates your blood pressure and makes your circulatory system deliver essential nutrients to your body much less efficiently
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