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When to stop treatment or seek urgent advice : Severe or persistent abdominal pain Significant increase in diarrhoea frequency or blood in stools Signs of dehydration (reduced urine output, dizziness, dry mouth) Symptoms suggesting Crohn's flare (fever, weight loss beyond expected, severe fatigue) Inability to tolerate oral intake due to nausea or vomiting Right upper quadrant pain, jaundice or fever (possible gallbladder disease) Patients should have direct access to their gastroenterology team and clear instructions on when to seek urgent medical review

N Engl J Med, 381(25), 24402450

With the advancement of modern detection technology, at least 23 endogenous sleep peptide substances have been discovered so far currently still under research

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They mimic the effects of the natural hormone (GLP-1) that regulates appetite, digestion and blood sugar levels