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Several cardiovascular outcome trials (CVOTs) have also reported that GLP-1 RAs may be associated with mitigating kidney-related outcomes, including albuminuria, decline in eGFR and the risk of end-stage kidney disease, independent of their effects on glycemic control 14,15,17,26,27
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Additionally, poison control centers reported a nearly 1,500 percent increase in calls since 2019 due to overdose or side effects
That said, regulatory standards differ, and even if retatrutide is approved abroad, distribution, cost, reimbursement, and access can lag behind
The addition of the Wegovy pill changes the conversation further
