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This system is highly expressed in astrocytes, the main GSH synthesizing cells in the brain, and is regulated by various factors, including oxidative stress and inflammatory cytokines Once synthesized, GSH can be metabolized by various enzymes, including glutathione S-transferases (GSTs), which conjugate GSH with xenobiotics and endogenous electrophiles for elimination, and gamma-glutamyl transpeptidase (GGT), which cleaves GSH into its constituent amino acids and generates extracellular glutamate, a major neurotransmitter in the brain

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

In PD mouse models, the intracellular domain of LRP1 (LRP1-ICD), released through -secretase and matrix metalloproteinase cleavage, accumulates within cells

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Enhances energy expenditure at the cellular level, aiding in weight management