Blood levels take about four weeks to settle after a step. The stomach-slowing effect that drives early nausea builds and then adapts over roughly the same window. And gut symptoms cluster at the first dose and at each increase, then ease with time on a held dose. The label waits for the last step to settle before adding the next
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Selection bias, regression to the mean, the placebo effect, and the simultaneous behavioural changes that often accompany a clinic visit (renewed attention to diet, restored adherence to protocols, increased motivation) all confound the interpretation of clinical-observation reports of this kind
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