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Similarly, NAD + levels appear reduced in preclinical models of age-associated diseases, including ataxia-telangiectasia (A-T), mitochondrial myopathies, and Alzheimers disease (AD), and disease-matched clinical samples 114,242,243,244,245,246

Recalcati S, et al

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Further, in a proposed model for UV-B-mediated signal transduction, the changes in the redox state and in GST gene expression were preceded by increased intracellular calcium levels in CHS-specific gene expression (Frohnmeyer and Staiger, 2003)