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RGN-352 was shown to be safe and well-tolerated with no serious drug-related adverse events reported (PMID: 20536472) Phase 2 AMI trial (incomplete): RegeneRx designed a Phase 2 proof-of-concept trial (NCT01311518) to evaluate RGN-352 in approximately 75 patients with acute ST-segment elevation myocardial infarction (heart attack)
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J Cell Sci 117:27912804 Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH (2010) Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex
In addition to this, the current mitophagy-related strategies used for the treatment of DKD, DR, DPN, and DCM are all based on experimental animal and cellular models, which are still a long way from clinical studies
L-Carnitine has been suggested to have an impact on appetite regulation by influencing the levels of certain hormones involved in hunger and satiety
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