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It has a shorter half-life in laboratory models, lasting approximately 30 minutes
KEAP1-NRF2: the cellular response to OS Structural insights KEAP1 and NRF2 are two relevant players in the molecular and cellular response to OS [114, 115]
308,309 EMT, CSCs, and DTPs are interconnected via regulatory networks involving transcription factors (e.g., SNAIL, ZEB1), 318 signaling cascades (e.g., TGF-), and cues from the TME (e.g., CAFs, hypoxia), collectively sustaining tumor heterogeneity and adaptive resistance
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