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SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)
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The GSTK1/RETREG1 complex conferred protection against diabetic tubular damage and kidney injury via modulating ER stress and apoptosis through the induction of reticulophagy, thereby revealing that maintaining ER homeostasis is crucial for the control of apoptosis (72, 111)
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