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In addition to activating expression of the S100G (CALB3) gene in the intestine, calcitriol also enhances the expression of several intestinal calcium transporter genes including the TRPV6 gene (encoding the transient receptor potential vanilloid 6 transporter), the SLC8A1 gene (encoding the Na + -Ca 2+ exchanger
Two grams (2,000 milligrams) seems to be the sweet spot for long-term effectiveness without health risks
It also works by reducing the tyrosinase enzyme, responsible for melanin production
with a BMI over 30 and uncontrolled hypertension despite treatment, advanced kidney disease or heart failure
& Jha, S
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