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Furthermore, K 197 , a highly conserved residue of GLP-1R, makes hydrogen bond interactions with T13 of GLP-1 ( 197 of GLP-1R (Figure 12)

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We also assess the potential mechanisms that contribute to the reduction in major adverse cardiovascular events in individuals treated with GLP1R agonists and highlight the emerging cardiovascular biology of novel GLP1-based multi-agonists currently in development