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GLP-1 and GIP receptor agonists seem to have a synergistic effect in weight reduction, although the mechanism is not yet clear [44]
This is especially relevant for older patients and those with significant weight to lose
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Tirzepatide activates two hormone receptors simultaneously: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)
The counter-argument is that mechanistic evidence is strong, multiple lines of clinical evidence converge, and the risk profile at microdose levels is favorable
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