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Total body weight loss is the headline metric from clinical trials, but researchers increasingly recognize that the quality of weight loss the ratio of fat mass to lean mass lost matters enormously for long-term metabolic health outcomes
They increase GLP-1 secretion
This broader mechanism may help explain why retatrutide has shown strong results in clinical trials
In fact, some studies suggest GLP-1/GIP medications may have protective effects against certain cancers by improving insulin sensitivity and reducing chronic inflammation
DeBakey VA Medical Center, Houston Minneapolis VA Medical Center, Minneapolis Orlando VA Medical Center, Orlando, Florida Palo Alto VA Medical Center, Palo Alto, California Philadelphia VA Healthcare System, Philadelphia Portland VA Medical Center, Portland, Oregon Tibor Rubin VA Medical Center, Long Beach, California VA Greater Los Angeles Health Care System, Los Angeles VA North Texas Health Care System, Dallas VA Puget Sound Health Care System, Seattle William S
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