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However, the magnitude of some of these observational estimates (for example, relative reductions in cardiovascular or all-cause mortality exceeding 50%) is considerably larger than would be predicted from the randomized effect sizes of either class and is almost certainly inflated by residual and time-related confounding, including healthy-adherer and prevalent-user biases
Cardiovascular disease and risk management: standards of care in diabetes 2023
The next generation of studies is, in that sense, as much a test of trial design and molecular delivery as of the hypothesis itself
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Experimental Pathology, 38 (3), 145164
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