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In an in-vivo models, IGF-1 influences adult dentate gyrus development by increasing the number of granule neurons and thus increasing the dentate granule cell layer [37, 38]
It was originally developed as an anti-obesity drug candidate because early research suggested it could stimulate lipolysis (fat breakdown) and reduce lipogenesis (fat formation) without the typical growth-promoting or IGF-1raising effects of full HGH
Barha et al., 2011
PMID: 14551133
Leuk Res 6(4):601-12, 1982
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