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The small molecule ligand was processed using AutoDockTools 1.5.7 software, including adding hydrogen bonds and assigning proper torsion angles to chemical bonds, and then exported in PDBQT format

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Safety profile in insulin-resistant populations The safety of Tirzepatide in insulin-resistant patients is a critical aspect of its clinical application: Hypoglycemia risk: Despite its potent glucose-lowering effects, Tirzepatide has shown a low risk of hypoglycemia, particularly when used as monotherapy