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M., Fasula, M., Krystal, J
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Traditional IEC purification of GLP-1 with salt gradients in aqueous solvents may, however, be problematic due to the lack of selectivity between a GLP-1 target moiety and related impurities.WO 98/08871 (The General Hospital Corporation) disclose peptide fragments which comprises GLP-1(7-37) and functional derivatives thereof and to its use as an insulinotropic agent.WO 87/06941 (The General Hospital Corporation) disclose peptide fragments which comprise GLP-1(7-36) and functional derivatives thereof and have an insulinotropic activity which exceeds the insulinotropic activity of GLP-1(1-36) or GLP-1(1-37) and to their use as insulinotropic agents.WO 90/11296 ) discloses analogues of the active GLP-1 peptides 7-34, 7-35, 7-36, and 7-37.WO 91/11457 (Buckley et al
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