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Published data suggests ipamorelin may increase IGF-1 levels by 15-30% in responder populations, while sermorelin studies report variable outcomes ranging from modest to moderate GH elevation depending on dosing, frequency, and baseline age

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Animal experiments have shown that rats treated with IGF-1 LR3 (0.3 mg/kg/d) for 8 consecutive weeks have a 2-fold increase in fasting insulin levels and a 1.8-fold increase in HOMA-IR index

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This represented a significant advancement over earlier weight loss medications and established semaglutide as the clinical benchmark for non-surgical medical weight management

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Initially studied for diabetes management and obesity, GLP-1 receptor agonists (GLP-1RAs) have garnered interest for their potential in addressing substance use disorders

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