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Moreover, safety risks are emerging, particularly when compounded formulations include substances not found in FDA-approved versions 1

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In further studies, eriodictyol (210, 211), calycosin (212), cudraflavone B (213), protocatechualdehyde (214), and naringin (215) exerted significant antitumor effects against several cancers including breast (MDA-MB-231), glioblastoma (A172, CHG-5, and U87 MG), ovarian (SKOV3), and liver (HepG2) cancer cells by promoting senescence, apoptosis, and interfering with GSK-3, TGF-1, SMAD2/3, SLUG, vimentin, -catenin, NF-B, COX-2, and cyclin D1, amongst other enzymes and signaling pathways