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2) Mitochondrial outer membrane crumpled or ruptured, mitochondrial crest reduced or absent, and mitochondria smaller

Participants were randomised to a target dose at baseline, and anyone discontinuing during escalation is still counted in the arm they were randomised to

Vitamin toxicity is another concern, especially with fat-soluble vitamins

Metallothioneins, the most important intracellular copper storage proteins, are also upregulated by GHK-Cu, providing an additional protective mechanism against copper-induced toxicity

Nurse support is included throughout the treatment period for clinical questions and ongoing guidance, providing a layer of ongoing access that helps patients navigate the titration phase without requiring scheduled appointments for every interaction