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This gap obscures the core drivers of progressive cognitive decline in AD

Hepatology 45 , 11181128, doi: 10.1002/hep.21635 (2007)

It confirmed ferroptosis as the core mechanism in PD pathogenesis synergistically induced by iron overload and inflammation, which activate ferroptosis by disrupting iron metabolism, inhibiting the antioxidant system and exacerbating lipid peroxidation, further causing dopaminergic neuronal damage, -syn aggregation, and PD-characteristic motor/cognitive impairments (186).Treating SH-SY5Y dopamine neurons with rotenone and using RhoNox-1 staining, followed by confocal microscopy observation and flow cytometry analysis, revealed significantly higher intracellular Fe 2+ in the rotenone group, confirming cellular iron overload (187)

But this incident highlights something much bigger than celebrity news its a real-world example of how pharmacogenomic (PGx) testing could save lives

Uhlen M, et al