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For the anti-CCR8 mAb1, the large difference we observe between its binding affinity and its IC50 of CCL1 inhibition suggests that engaging additional or other extracellular regions than ECL2 may yield stronger CCL1 blocking activity (Fig
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The decrease in body weight in the groups given sitagliptin in combination with metformin was similar to that in the groups given metformin alone or placebo
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