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Extremes matter: patients under 50 kg often do well at the lower end, patients over 100 kg may sit at the upper end of standard ranges

Senescent cells stop producing collagen, begin secreting enzymes that degrade existing collagen and elastin, and create a local inflammatory environment that accelerates surrounding tissue aging

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This is from immediate barrier support, not collagen changes

Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure