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Another unknown is what happens when large numbers of people use these drugs in the real world, outside the controlled environment of a clinical trial
These include: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting and diarrhoea Constipation and abdominal discomfort Decreased appetite , which, whilst contributing to weight loss, can occasionally lead to inadequate nutritional intake Most gastrointestinal effects were described as mild to moderate in severity and tended to diminish over time
For people with type 2 diabetes, it's worth noting that rapid improvement in glycaemic control with GLP-1 receptor agonists like semaglutide has been associated with worsening of diabetic retinopathy in some cases, requiring appropriate monitoring
It stimulates insulin secretion during normoglycemia and influences lipid storage, though its metabolic effects are highly context-dependent 1
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