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COGNITIVE FUNCTION AND NEUROPROTECTION Neurogenic Effects of GH/IGF-1: Hippocampal neurogenesis: increase in new cells 40% Synaptic plasticity: Long-term potentiation (LTP) BDNF: Upregulation of 60% in the hippocampus/cortex Myelination: oligodendrocyte support, white matter integrity Cognitive Function: Spatial Memory: Morris Water Maze 30% Improvement Working memory: enhanced T-maze performance Processing speed: reduced response times 15% Neuroprotection: Reduction of neuronal death in ischemia models 45% Neurodegenerative Models Alzheimer's: 30% -amyloid reduction, improved cognition Parkinson's Disease: Protection of Dopaminergic Neurons 40% Aging: Partial Reversal of Age-Related Cognitive Decline 4
[45] Models of ADHD suggest that it is associated with functional impairments in some of the brain's neurotransmitter systems
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doi:10.4103/2230-8210.131155 [103] Bin Waqar SH, Rehan A
It is a single molecule with balanced agonist activity at both the GLP-1 receptor and the GIP receptor, marketed as Mounjaro for type 2 diabetes and Zepbound for obesity
