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(Albin 2022) [#2] Maintenance dose : Starting dose is generally 1.66-2.33 PE/kg IV q8hr (e.g., ~100 mg IV q8hr)
People on the maximum dose lost an average of 85 lb after the full 104 weeks, or about 30 percent of their starting weight
Full publication of combination-therapy data is awaited, however interim analysis from the phase II COURAGE trial (NCT06299098) found 3.3% reduction in lean mass of obese patients treated with the combination of trevogrumab and semaglutide, compared with 6.5% reduction with semaglutide alone [70]
Its not entirely surprising that something similar could happen with blood sugar. This hypothesis aligns with the experiences of diabetic patients, who often report temporary blurring of vision when their blood sugar levels fluctuate
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