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In April 2026, the FDA granted approval to two oral GLP-1 treatments, Eli Lillys Foundayo, made with orforglipron, and Novo Nordisks semaglutide pill, also called Wegovy
Two separate human clinical trials have investigated this compound: Ulcerative Colitis Trial Clinical investigation of this compound in patients with ulcerative colitis examined the compounds GI-protective properties properties that are consistent with its gastric origin and documented activity on intestinal permeability barriers in animal models
See the peptide side effects guide for additional safety context
In one sample, only caffeine was found
Depression: from psychopathology to pathophysiology, Curr Opin Neurobiol, 2015;30:24-30
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