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Dosing Strategy and Formulation Choices to Minimize Headache Occurrence Slower titration schedulesstarting at 2.5 mg weekly for 4 weeks before escalationreduce headache incidence compared to standard 5 mg initiation

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PLEASE NOTE: Clinical trials have indicated that Retatrutide may lead to greater average weight loss than tirzepatide, another dual-agonist medication, although retatrutide is still investigational and not yet FDA-approved

Iwai, S

Consistent with the greater weight loss effect, significantly greater reductions in BMI, waist and neck circumference were also observed with liraglutide compared with placebo