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J Clin Endocrinol.Metab 2008;93(7):2559-2565

mega-doses (e.g., 6 mg) have been linked to severe systemic toxicity and rhabdomyolysis

[7] [8] It turned out that this effect was due to a small peptide factor that behaved similarly to the synthetic peptide glycyl-L-histidyl-L-lysine (GHK)

This 'adaptive thermogenesis' is your body's way of defending against perceived starvation, making post-medication periods especially vulnerable

One strength of the study is that the sample size is very large and includes data from all 50 states, and over 1,300 hospitals. However, since the study is retrospective and lacks many of the controls of a randomized controlled trial, its important to be careful about drawing conclusions