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Moreover, liraglutide trials in patients with HFrEF provided no clinical benefit, underscoring that the efficacy of incretin receptor agonism does not uniformly extend across heart-failure phenotypes and that remodelling mechanisms may differ by disease context [47]
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Severe gastrointestinal symptoms during semaglutide treatment, including persistent nausea, vomiting, or diarrhea, warrant medical consultation, particularly in anticoagulated patients
Risk of Infection As with any procedure that involves needles, there is a risk of infection at the injection site
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