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If sleep problems persist , a temporary low-dose melatonin supplement (0.5 to 1 mg, not the 5 to 10 mg doses commonly sold) can help reset circadian rhythm without creating dependence

4, 5 Despite this success, about 50% of patients do not benefit from tamoxifen and frequent adverse drug reactions (ADR) including hot flashes, vasomotor and gynecologic symptoms as well as depression and diminished sexual functioning prevent particularly young women from staying on the drug

Uncontrolled hypertension silently damages the heart, brain, and kidneys increasing the risk of stroke, myocardial infarction, heart failure, and renal disease

It would be an even smaller price to pay if

J Trace Elem Med Biol 67:126801