can you abruptly stop tirzepatide U Just Taking Mounjaro? Safety and What to Expect – PlexusDx Do You Need To Taper

Of note, in the SURPASS-4 trial, adjudicated major adverse cardiovascular events (MACE) were not increased with tirzepatide compared with insulin glargine over an extended follow-up period of 52 additional weeks after the main trial period of 52 weeks [21]

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DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, OKeefe JH: L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis

Also, long-term safety data is still limited since it is only in Phase 3 especially around muscle loss vs fat loss, cardiovascular outcomes beyond surrogate markers, and durability after discontinuation

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