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The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study

Im very excited about it, because I think now we have a chance to really understand this down to the cellular level, says Trapp

Obesity rates have sharply increased in both established and emerging economies due to sedentary lifestyles, poor nutritional practices, and urbanization

The goal is not to eliminate exercise-induced oxidative stress entirely, which would potentially impair training adaptations, but to ensure that antioxidant defenses remain adequate to prevent excessive cellular damage while allowing beneficial adaptive signaling to occur