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In a manner similar to that of an NKF Carnitine Consensus Conference and in line with the recommendation from the prior K/DOQI Pediatric Nutrition Guidelines, the Work Group believes that a trial may be indicated when all other causes for the symptoms in question have been excluded and the patient has been unresponsive to standard therapies

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Presented for research literature review only Mguez JM et al

This reduction in risk occurred early in the trial before participants had lost a lot of weight