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Serious reactions, including allergic responses, are rare
But for most patients, the headaches are a transient signal that the medication is actively reshaping metabolic function
Clinical trials show that semaglutide's weight loss benefits increase with dose, but the relationship is not linear and plateaus vary by individual
However, GLP-1 as a hormone is rapidly broken down in the body, limiting the duration that it can induce these effects
The risk of hypoglycemia increases when tirzepatide is used with insulin or sulfonylureas
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