The rationale rests more on theoretical benefit and observed clinical patterns than controlled trial evidence
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These newer-generation SUs are often superior to other drug classes in terms of speed in achieving in glycemic control, offer better protection against adverse cardiac and renal outcomes, and show low incidences of untoward side effects that can rival those of other DM drugs, making them the safer option among SUs
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To the reaction mixture, containing deprotected pentapeptide hydrochloride and Pd(OH) 2 , was added a solution of Z-Asp( O t Bu)-OPfp (26.3 g) in THF (150 mL), and the resulting mixture was stirred for 1 h at r.t