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Intranuclear TCA and mitochondrial overload: the nascent sprout of tumors metabolism
Fellow senior author Elizabeth Jaffee, MD, deputy director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, commented that prevention and interception "save lives and reduce the morbidity associated with cancer development and progression." "This is especially important for cancers whose early-onset frequency is increasing and for which we do not have effective methods for early detection," she added in the release
Pharmacokinetic profiles for the compound place its plasma half-life in the neighborhood of 45 minutes after parenteral administration in animal models, which informs typical dosing intervals in published experiments
The maximum number of simultaneous overlapping MRM transitions within any given retention window did not exceed 10, which is well within the theoretical and practical limits of the instrument
Anal Biochem 529:127143 Aoyama K, Nakaki T (2013) Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1)
